Publicaciones de integrantes de la Sección Biología Celular

Nota: Esta página se está construyendo. Iremos agregando publicaciones en revistas científicas así como en libros donde los integrantes de la sección son autores o coautores, ordenados por año. Solamente incluimos publicaciones de los docentes que integran la Sección desde 2017. En negrita se resaltan los coautores que son integrantes actuales o previos de la Sección.


Kaethner M, Epping K, Bernthaler P, Rudolf K, Thomann I, Leitschuh N, Bergmann M, Spiliotis M, Koziol U, Brehm K (2023). Transforming growth factor-β signalling regulates protoscolex formation in the Echinococcus multilocularis metacestode. Front Cell Infect Microbiol. 13:1153117

Millán M, Villarreal L, D'Aiuto N, Bologna-Molina R, Sotelo-Silveira J, Benech JC, Hochmann J, Arocena M (2003) Mechanical profile of human keratinocytes expressing HPV-18 oncogenes. Biochem Biophys Res Comm 657:86-91.

Aguilera E, Sánchez C, Cruces ME, Dávila B, Minini L, Mosquillo F, Pérez-Díaz L, Serna E, Torres S, Schini A, Sanabria L, Vera de Bilbao NI, Yaluff G, Zolessi FR, Ceilas LF, Cerecetto H, Alvarez G (2023) Preclinical studies and drug combination of low-cost molecules for Chagas Disease. Pharmaceuticals 16(1):20. doi: 10.3390/ph16010020

Calvelo J, Brehm K, Iriarte A, Koziol U. (2023) Trans-splicing in the cestode Hymenolepis microstoma is constitutive across the life cycle and depends on gene structure and composition. Int J Parasitol. 2023 Feb;53(2):103-117. doi: 10.1016/j.ijpara.2022.11.006

Müller, J., Preza, M., Kaethner, M., Rufener, R., Braga, S., Uldry, A.-C., Heller, M., Lundström-Stadelmann, B. (2023) Targeted and non-targeted proteomics to characterize the parasite proteins of Echinococcus multilocularis metacestodes. Frontiers in Cellular and Infection Microbiology 13.

Memedovski, R., Preza, M., Müller, J., Kämpfer, T., Rufener, R., de Souza, M.V.N., da Silva, E.T., de Andrade, G.F., Braga, S., Uldry, A.-C., Buchs, N., Heller, M., Lundström-Stadelmann, B. (2023) Investigation of the mechanism of action of mefloquine and derivatives against the parasite Echinococcus multilocularis. Int J Parasitol Drugs Drug Resist 21, 114–124.

Kaethner, M., Preza, M., Kaempfer, T., Zumstein, P., Tamponi, C., Varcasia, A., Hemphill, A., Brehm, K., Lundström-Stadelmann, B. (2023) Establishment and application of unbiased in vitro drug screening assays for the identification of compounds against Echinococcus granulosus sensu stricto. PLOS Neglected Tropical Diseases 17, e0011343.


D’Aiuto N, Hochmann J, Millán M, Di Paolo A, Bologna-Molina R, Sotelo Silveira J, Arocena M (2022) Hypoxia, acidification and oxidative stress in cells cultured at large distances from an oxygen source. Scientific Reports 12, 21699. DOI: 10.1038/s41598-022-26205-y 

Fort RS, Chavez S, Trinidad Barnech JM, Oliveira-Rizzo C, Smircich P, Sotelo-Silveira JR, Duhagon MA (2022) Current Status of Regulatory Non-Coding RNAs Research in the Tritryp. Noncoding RNA 8(4):54. doi: 10.3390/ncrna8040054

Domínguez MF, Costábile A, Koziol U, Preza M, Brehm K, Tort JF, Castillo E. (2022) Cell repertoire and proliferation of germinative cells of the model cestode Mesocestoides corti. Parasitology 149(11):1505-1514. doi: 10.1017/S0031182022000956

Preza M, Van Bael S, Temmerman L, Guarnaschelli I, Castillo E, Koziol U (2022) Global analysis of neuropeptides in cestodes identifies Attachin, a SIFamide homolog, as a stimulant of parasite motility and attachment. J. Neurochem. 162(6):467-482. doi: 10.1111/jnc.15654

Davison C, Bedó G, Zolessi FR (2022) Zebrafish Slit2 and Slit3 act together to regulate retinal axon crossing at the midline. J. Dev. Biol. 10(4), 41. doi: 10.3390/jdb10040041 Preprint: bioRxiv

Vázquez Alberdi L, Rosso G, Veloz L, Romeo C, Farias J, Di Tomaso MV, Calero M, Kun A (2022) Curcumin and Ethanol Effects in Trembler-J Schwann Cell Culture. Biomolecules 12(4):515. doi: 10.3390/biom12040515

Veloz L, Bosch SA, Aparicio G, Zolessi FR (2022) Cell extrusion in development and cancer, what MARCKS the difference for epithelial integrity? BIOCELL 46(3) 639-644. doi:10.32604/biocell.2022.018798.

Camicia F, Vaca HR, Guarnaschelli I, Koziol U, Mortensen OV, Fontana ACK (2022) Molecular characterization of the serotonergic transporter from the cestode Echinococcus granulosus: pharmacology and potential role in the nervous system. Parasitol Res, epub ahead of print. doi: 10.1007/s00436-022-07466-y

Eastman G, Sharlow ER, Lazo JS, Bloom GS, Sotelo-Silveira JR (2022) Transcriptome and Translatome Regulation of Pathogenesis in Alzheimer's Disease Model Mice. J Alzheimers Dis 86(1):365-386. doi: 10.3233/JAD-215357

Oliveira-Rizzo C, Ottati MC, Fort RS, Chavez S, Trinidad JM, DiPaolo A, Garat B, Sotelo-Silveira JR, Duhagon MA (2022) Hsa-miR-183-5p Modulates Cell Adhesion by Repression of ITGB1 Expression in Prostate Cancer. Noncoding RNA 8(1):11. doi: 10.3390/ncrna8010011

Chaudhry, S., Zurbriggen, R., Preza, M., Kämpfer, T., Kaethner, M., Memedovski, R., Scorrano, N., Hemphill, A., Doggett, J.S., Lundström-Stadelmann, B. (2022) Dual inhibition of the Echinococcus multilocularis energy metabolism. Front Vet Sci 9, 981664.


Chalar C, Clivio G, Montagne J, Costábile A, Lima A, Papa NG, Berois N, Arezo MJ (2021) Embryonic developmental arrest in the annual killifish Austrolebias charrua: A proteomic approach to diapause III. PLoS One 16(6):e0251820. doi: 10.1371/journal.pone.0251820

Camicia F, Vaca HR, Park SK, Bivona AE, Naidich A, Preza M, Koziol U, Celentano AM, Marchant JS, Rosenzvit MC (2021) Characterization of a new type of neuronal 5-HT G- protein coupled receptor in the cestode nervous system. PLoS One 16(11):e0259104. doi: 10.1371/journal.pone.0259104

Mesquita-Ribeiro R, Fort RS, Rathbone A, Farias J, Lucci C, James V, Sotelo-Silveira J, Duhagon MA, Dajas-Bailador F (2021) Distinct small non-coding RNA landscape in the axons and released extracellular vesicles of developing primary cortical neurons and the axoplasm of adult nerves. RNA Biol. 9:1-24. doi: 10.1080/15476286.2021.2000792. 

Rodríguez-Esperón MC, Eastman G, Sandes L, Garabato F, Eastman I, Iriarte A, Fabiano E, Sotelo-Silveira JR, Platero R (2021) Genomics and transcriptomics insights into luteolin effects on the beta-rhizobial strain Cupriavidus necator UYPR2.512. Environ Microbiol. doi: 10.1111/1462-2920.15845. 

Chávez S, Urbaniak MD, Benz C, Smircich P, Garat B, Sotelo-Silveira JR, Duhagon MA (2021) Extensive Translational Regulation through the Proliferative Transition of Trypanosoma cruzi Revealed by Multi-Omics. mSphere 6(5):e0036621. doi: 10.1128/mSphere.00366-21. 

Di Paolo A, Garat J, Eastman G, Farias J, Dajas-Bailador F, Smircich P, Sotelo-Silveira JR (2021) Functional Genomics of Axons and Synapses to Understand Neurodegenerative Diseases. Front Cell Neurosci. 15:686722. doi: 10.3389/fncel.2021.686722. 

Dufort Y Álvarez G, Seroussi G, Smircich P, Sotelo-Silveira J, Ochoa I, Martín Á (2021) RENANO: a REference-based compressor for NANOpore FASTQ files. Bioinformatics.  15:btab437. doi: 10.1093/bioinformatics/btab437. 

Mir D, Rego N, Resende PC, Tort F, Fernández-Calero T, Noya V, Brandes M, Possi T, Arleo M, Reyes N, Victoria M, Lizasoain A, Castells M, Maya L, Salvo M, Schäffer Gregianini T, Mar da Rosa MT, Garay Martins L, Alonso C, Vega Y, Salazar C, Ferrés I, Smircich P, Sotelo Silveira J, Fort RS, Mathó C, Arantes I, Appolinario L, Mendonça AC, Benítez-Galeano MJ, Simoes C, Graña M, Motta F, Siqueira MM, Bello G, Colina R, Spangenberg L (2021) Recurrent Dissemination of SARS-CoV-2 Through the Uruguayan-Brazilian Border. Front Microbiol. 12:653986. doi: 10.3389/fmicb.2021.653986. 

Di Paolo A, Farias J, Garat J, Macklin A, Ignatchenko V, Kislinger T, Sotelo Silveira J (2021) Rat Sciatic Nerve Axoplasm Proteome Is Enriched with Ribosomal Proteins during Regeneration Processes. J Proteome Res. 20(5):2506-2520. doi: 10.1021/acs.jproteome.0c00980

Preza M, Guarnaschelli I, Castillo E, Koziol U (2021). Inhibitors of protein kinases A and C impair the motility of oncospheres of the model tapeworm Hymenolepis microstoma. Mol Biochem Parasitol. 246:111423. doi: 10.1016/j.molbiopara.2021.111423.

Lepanto P, Levin-Ferreyra F, Koziol U, Malacrida L, Badano JL. (2021). Insights into in vivo adipocyte differentiation through cell-specific labeling in zebrafish. Biol Open.10(9):bio058734. doi: 10.1242/bio.058734.

Orrego MA, Verastegui MR, Vasquez CM, Koziol U, Laclette JP, Garcia HH, Nash TE, Cysticercosis Working Group in Peru (2021). Identification and culture of proliferative cells in abnormal Taenia solium larvae: Role in the development of racemose neurocysticercosis. PLoS Negl Trop Dis. 2021 Mar 22;15(3):e0009303.

Macchiaroli N, Preza M, Pérez MG, Kamenetzky L, Cucher M, Koziol U, Castillo E, Berriman M, Brehm K, Rosenzvit MC (2021). Expression profiling of Echinococcus multilocularis miRNAs throughout metacestode development in vitro. PLoS Negl Trop Dis. 2021 Mar 22;15(3):e0009297.

Davison C, Zolessi FR (2021) Slit2 is necessary for optic axon organization in the zebrafish ventral midline. Cells Dev, 203677. doi: 10.1016/j.cdev.2021.203677 Preprint:

Lupo G, Piper M, Zolessi FR (2021) Editorial: Context-dependent regulation of neurogenesis: common themes and unique features of the neurogenic process in different model systems. Front. Cell Dev. Biol. 9:678475. doi: 10.3389/fcell.2021.678475.

Preza M, Calvelo J, Langleib M, Hoffmann F, Castillo E, Koziol U, Iriarte A (2021) Stage-specific transcriptomic analysis of the model cestode Hymenolepis microstoma. Genomics. 113: 620–632.

Zolessi FR, Berois N, Brauer MM, Castillo E (2021) Building the embryo of developmental biology in Uruguay. Intl J Devl Biol 65: 71 - 76. doi: 10.1387/ijdb.200141fz 

Aparicio G, Rodao M, Badano JL, Zolessi FR (2021) Photoreceptor progenitor dynamics in the zebrafish embryo retina and its modulation by primary cilia and N-cadherin. Int. J. Dev. Biol. 65: 439 - 455. doi: 10.1387/ijdb.200113fz. Preprint:


Castillo E, Koziol U (2020) Analysis of Gene Expression in Fasciola hepatica Juveniles and Adults by In Situ Hybridization. Methods Mol Biol 2137:93-105. doi: 10.1007/978-1-0716-0475-5_7.

Di Paolo A, Eastman G, Mesquita-Ribeiro R, Farias J, Macklin A, Kislinger T, Colburn N, Munroe D, Sotelo Sosa JR, Dajas-Bailador F, Sotelo-Silveira JR (2020) PDCD4 regulates axonal growth by translational repression of neurite growth-related genes and is modulated during nerve injury responses. RNA. 26(11):1637-1653. doi: 10.1261/rna.075424.120

Canclini L, Farias J, Di Paolo A, Sotelo-Silveira JR, Folle G, Kun A, Sotelo JR (2020) Association of microtubules and axonal RNA transferred from myelinating Schwann cells in rat sciatic nerve. PLoS One. 15(5):e0233651. doi: 10.1371/journal.pone.0233651. 

Fort RS, Garat B, Sotelo-Silveira JR, Duhagon MA (2020) vtRNA2-1/nc886 Produces a Small RNA That Contributes to Its Tumor Suppression Action through the microRNA Pathway in Prostate Cancer. Noncoding RNA. 6(1):7. doi: 10.3390/ncrna6010007.

Farias J, Holt CE, Sotelo JR, Sotelo-Silveira JR (2020) Axon microdissection and transcriptome profiling reveals the in vivo RNA content of fully differentiated myelinated motor axons. RNA.26(5):595-612. doi: 10.1261/rna.073700.119. 

Trovero MF, Rodríguez-Casuriaga R, Romeo C, Santiñaque FF, François M, Folle GA, Benavente R, Sotelo-Silveira JR, Geisinger A (2020) Revealing stage-specific expression patterns of long noncoding RNAs along mouse spermatogenesis. RNA Biol. 17(3):350-365. doi: 10.1080/15476286.2019.1700332.

Calvelo J, Juan H, Musto H, Koziol U, Iriarte A (2020) SLFinder, a pipeline for the novel identification of splice-leader sequences: a good enough solution for a complex problem Bioinformatics 21, 293.


Montagne J, Preza M, Castillo E, Brehm K, Koziol U. (2019). Divergent Axin and GSK-3 paralogs in the beta-catenin destruction complexes of tapeworms. Dev Genes Evol. 2019 Jul;229(4):89-102.

Förster S, Koziol U, Schäfer T, Duvoisin R, Cailliau K, Vanderstraete M, Dissous C, Brehm K. (2019) The role of fibroblast growth factor signalling in Echinococcus multilocularis development and host-parasite interaction. PLoS Negl Trop Dis. 8;13(3):e0006959. doi:10.1371/journal.pntd.0006959

Amarelle V, Koziol U, Fabiano E (2019). Highly conserved nucleotide motifs present in the 5'UTR of the heme-receptor gene shmR are required for HmuP-dependent expression of shmR in Ensifer meliloti. Biometals (en prensa).

Lepanto P., Zolessi F.R., Badano J.L. (2019) Studying human genetic variation in zebrafish. En: Cellular and Animal Models in Human Genomics Research (Translational and Applied Genomics Series). Eds.: Walz K, Young JI. San Diego: Elsevier Inc./Academic Press. Pág. 89-117. doi: 10.1016/B978-0-12-816573-7.00005-5

Santos L, Colman L, Contreras P, Chini CC, Carlomagno A, Leyva A, Bresque M, Marmisolle I, Quijano C, Durán R, Irigoín F, Prieto-Echagüe V, Vendelbo MH, Sotelo-Silveira JR, Chini EN, Badano JL, Calliari AJ, Escande C (2019) A novel form of Deleted in breast cancer 1 (DBC1) lacking the N-terminal domain does not bind SIRT1 and is dynamically regulated in vivo. Sci Rep. 2019 Oct 7;9(1):14381. doi: 10.1038/s41598-019-50789-7.

Papa NG, Chalar C , Berois, N , Arezo, MJ (2019). Annual killifish: an approach to the choriogenins of Austrolebias charrua egg envelope. Environmental Biology of Fishes 102:829–844.


Preza M, Montagne J, Costábile A, Iriarte A, Castillo E, Koziol U. (2018) Analysis of classical neurotransmitter markers in tapeworms: Evidence for extensive loss of neurotransmitter pathways. Int J Parasitol. 48(13):979-992. doi: 10.1016/j.ijpara.2018.06.004.

Koziol U. (2018) Precursors of neuropeptides and peptide hormones in the genomes of tardigrades. Gen Comp Endocrinol. 267:116-127. doi:10.1016/j.ygcen.2018.06.012.

Costábile A, Koziol U, Tort JF, Iriarte A, Castillo E. (2018) Expansion of cap superfamily proteins in the genome of Mesocestoides corti: An extreme case of a general bilaterian trend. Gene Reports 11:110-120.

Aparicio G, Arruti C, Zolessi FR (2018) MARCKS phosphorylation by PKC strongly impairs cell polarity in the chick neural plate. Genesis, 56(4):e23104. doi: 10.1002/dvg.23104 

Arocena M, Pérez Zerpa JM, Di Paolo A, Aguilera PA, Sotelo-Silveira J. (2018) Lamellipodial wrinkles in fish keratocytes as markers of imperfect coordination between extension and retraction during cell migration. Biochem Biophys Res Commun. 498(3):680-685. doi: 10.1016/j.bbrc.2018.03.045

Paravani E.V., Simoniello M.F., Poletta G.L., Zolessi F.R., Casco V.H. (2018) Cypermethrin: Oxidative stress and genotoxicity in retinal cells of the adult zebrafish. Mutat Res. 826:25-32. doi: 10.1016/j.mrgentox.2017.12.010.

Fort RS, Mathó C, Geraldo MV, Ottati MC, Yamashita AS, Saito KC, Leite KRM, Méndez M, Maedo N, Méndez L, Garat B, Kimura ET, Sotelo-Silveira JR, Duhagon MA. (2018) Nc886 is epigenetically repressed in prostate cancer and acts as a tumor suppressor through the inhibition of cell growth. BMC Cancer. 18(1):127. doi: 10.1186/s12885-018-4049-7.

Eastman G, Smircich P, Sotelo-Silveira JR (2018) Following Ribosome Footprints to Understand Translation at a Genome Wide Level. Comput Struct Biotechnol J. 16:167-176. doi: 10.1016/j.csbj.2018.04.001. 

Fort RS, Mathó C, Oliveira-Rizzo C, Garat B, Sotelo-Silveira JR, Duhagon MA (2018) An integrated view of the role of miR-130b/301b miRNA cluster in prostate cancer. Exp Hematol Oncol. 7:10. doi: 10.1186/s40164-018-0102-0. 

Sotelo-Silveira M, Chávez Montes RA, Sotelo-Silveira JR, Marsch-Martínez N, de Folter S (2018) Entering the Next Dimension: Plant Genomes in 3D. Trends Plant Sci. 2018 Jul;23(7):598-612. doi: 10.1016/j.tplants.2018.03.014.

Novas R, Cardenas-Rodriguez M, Lepanto P, Fabregat M, Rodao M, Fariello MI, Ramos M, Davison C, Casanova G, Alfaya L, Lecumberry F, González-Sapienza G, Irigoín F, Badano JL. (2018) Kinesin 1 regulates cilia length through an interaction with the Bardet-Biedl syndrome related protein CCDC28B. Sci Rep. 8(1):3019. doi: 10.1038/s41598-018-21329-6.


Koziol U. (2017) Evolutionary developmental biology (evo-devo) of cestodes. Exp Parasitol. 180:84-100. doi: 10.1016/j.exppara.2016.12.004. 

Chávez S, Eastman G, Smircich P, Becco LL, Oliveira-Rizzo C, Fort R, Potenza M, Garat B, Sotelo-Silveira JR, Duhagon MA (2017) Transcriptome-wide analysis of the Trypanosoma cruzi proliferative cycle identifies the periodically expressed mRNAs and their multiple levels of control. PLoS One. 12(11):e0188441. doi: 10.1371/journal.pone.0188441

Marcon BH, Holetz FB, Eastman G, Origa-Alves AC, Amorós MA, de Aguiar AM, Rebelatto CK, Brofman PRS, Sotelo-Silveira J, Dallagiovanna B.(2017) Downregulation of the protein synthesis machinery is a major regulatory event during early adipogenic differentiation of human adipose-derived stromal cells. Stem Cell Res. 25:191-201. doi: 10.1016/j.scr.2017.10.027

Rozenblum E, Sotelo-Silveira JR, Kim GY, Zhu JY, Lau CC, McNeil N, Korolevich S, Liao H, Cherry JM, Munroe DJ, Ried T, Meltzer PS, Kuehl WM, Roschke AV. (2017) Novel near-diploid ovarian cancer cell line derived from a highly aneuploid metastatic ovarian tumor. PLoS One. 12(8):e0182610. doi: 10.1371/journal.pone.0182610

Prieto D, Aparicio G, Sotelo-Silveira JR. (2017) Cell migration analysis: A low-cost laboratory experiment for cell and developmental biology courses using keratocytes from fish scales. Biochem Mol Biol Educ. doi: 10.1002/bmb.21071.

Prieto D., Zolessi F.R. (2017) Functional diversification of the four MARCKS family members in zebrafish neural development. J. Exp. Zool. (Mol. Dev. Evol.) 328(1-2):119-138. doi: 10.1002/jez.b.22691.

Álvarez G., Perdomo C., Coronel C., Aguilera E., Varela J., Aparicio G., Zolessi F.R., Cabrera N., Vega C., Rolón M., Rojas De Arias A., Pérez-Montfort R., Cerecetto H., González M. (2017) Multi-anti-parasitic activity of arylideneketones and thiazolidenehydrazines against Trypanosoma cruzi and Leishmania spp. Molecules 22(5). pii: E709. doi: 10.3390/molecules22050709.

Brehm K, Koziol U. (2017) Echinococcus-Host Interactions at Cellular and Molecular Levels. Adv Parasitol. 95:147-212. doi: 10.1016/bs.apar.2016.09.001.

Pastro L, Smircich P, Di Paolo A, Becco L, Duhagon MA, Sotelo-Silveira J, Garat B. (2017) Nuclear Compartmentalization Contributes to Stage-Specific Gene Expression Control in Trypanosoma cruzi. Front Cell Dev Biol. 5:8. doi: 10.3389/fcell.2017.00008.

Berois N, Garcia G, De Sá RO. (2017) A global community effort to decipher the unique biology of annual killifish. Dev Dyn. 246(11):807-811. doi: 10.1002/dvdy.24533.

Arezo MJ, Papa NG, Berois N, Clivio G, Montagne J, De la Piedra S. (2017) Annual killifish adaptations to ephemeral environments: Diapause i in two austrolebias species. Dev Dyn. 246(11):848-857. doi: 10.1002/dvdy.24580

Arocena M, Rajnicek AM, Collinson JM. (2017) Requirement of Pax6 for the integration of guidance cues in cell migration. R Soc Open Sci. 4(10):170625. doi: 10.1098/rsos.170625


Lepanto P., Badano J.L., Zolessi F.R. (2016) Neuron’s little helper: the role of primary cilia in neurogenesis. Neurogenesis. 3:1, e1253363. DOI: 10.1080/23262133.2016.1253363

Lepanto P., Davison C., Casanova G., Badano J.L., Zolessi F.R. (2016) Characterization of primary cilia during the differentiation of retinal ganglion cells in the zebrafish. Neural Dev. 11(1):10. doi: 10.1186/s13064-016-0064-z. 

Zolessi F.R. (2016) Vertebrate neurogenesis: cell polarity (v. 3). Encyclopedia of Life Sciences (Wiley). DOI: 10.1002/9780470015902.a0000826.pub3

Schulz A, Büttner R, Toledo A, Baader SL, von Maltzahn J, Irintchev A, Bauer R, Morrison H. (2016) Neuron-Specific Deletion of the Nf2 Tumor Suppressor Impairs Functional Nerve Regeneration. PLoS One. 11(7):e0159718. doi: 10.1371/journal.pone.0159718.

Iriarte A, Platero R, Romero V, Fabiano E, Sotelo-Silveira JR. (2016) Draft Genome Sequence of Cupriavidus UYMMa02A, a Novel Beta-Rhizobium Species. Genome Announc. 4(6). pii: e01258-16. doi: 10.1128/genomeA.01258-16.

Giorello FM, Romero V, Farias J, Scavone P, Umpiérrez A, Zunino P, Sotelo Silveira JR. (2016) Draft Genome Sequence and Gene Annotation of the Uropathogenic Bacterium Proteus mirabilis Pr2921. Genome Announc. 4(3). pii: e00564-16. doi: 10.1128/genomeA.00564-16.

da Cruz I, Rodríguez-Casuriaga R, Santiñaque FF, Farías J, Curti G, Capoano CA, Folle GA, Benavente R, Sotelo-Silveira JR, Geisinger A. (2016) Transcriptome analysis of highly purified mouse spermatogenic cell populations: gene expression signatures switch from meiotic-to postmeiotic-related processes at pachytene stage. BMC Genomics. 17:294. doi: 10.1186/s12864-016-2618-1.

Koziol U, Koziol M, Preza M, Costábile A, Brehm K, Castillo E. (2016) De novo discovery of neuropeptides in the genomes of parasitic flatworms using a novel comparative approach. Int J Parasitol. 46(11):709-21. doi: 10.1016/j.ijpara.2016.05.007. 

Koziol U, Jarero F, Olson PD, Brehm K. (2016) Comparative analysis of Wnt expression identifies a highly conserved developmental transition in flatworms. BMC Biol. 14:10. doi: 10.1186/s12915-016-0233-x.

Del Puerto L, Rovetta R, Navatta M, Fontana C, Lin G, Moyna G, Dematteis S, Brehm K, Koziol U, Ferreira F, Díaz A. (2016) Negligible elongation of mucin glycans with Gal β1-3 units distinguishes the laminated layer of Echinococcus multilocularis from that of Echinococcus granulosus. Int J Parasitol. 46(5-6):311-21. doi: 10.1016/j.ijpara.2015.12.009.

Arezo MJ, Papa N, Berois N, García, G., Gutiérrez, V., Antonelli, M. (2016) Sex determination and differentiation in annual fishes. En: Annual fishes: life history strategy, diversity and evolution. vol.: 1 , 1, p.: 73 - 90,Editores: Nibia Berois, Graciela García, Rafael de Sá. Editorial: CRC Press Taylor and Francis. ISSN/ISBN: 9781482299717.

Berois N, Arezo MJ, Papa N, Chalar C. (2016) Life cycle, reproduction and development in annual fishes: cellular and molecular aspects. En: Annual fishes: life history strategy, diversity and evolution. vol.: 1 , 1, p.: 31 - 43, Editores: Nibia Berois, Graciela García, Rafael de Sá. Editorial: CRC Press Taylor and Francis Group ,ISSN/ISBN: 978148229971.


Prieto D., Aparicio G., Machado, M., Zolessi F.R. (2015) Application of the DNA-Specific Stain Methyl Green in the Fluorescent Labeling of Embryos. J. Vis. Exp. (99), e52769, doi: 10.3791/52769.

Paolini A, Duchemin AL, Albadri S, Patzel E, Bornhorst D, González Avalos P, Lemke S, Machate A, Brand M, Sel S, Di Donato V, Del Bene F, Zolessi FR, Ramialison M, Poggi L. (2015) Asymmetric inheritance of the apical domain and self-renewal of retinal ganglion cell progenitors depend on Anillin function. Development 142(5): 832-9. doi: 10.1242/dev.118612

Koziol U, Brehm K (2015). Recent advances in Echinococcus genomics and stem cell research. Vet Parasitol. 213(3-4):92-102. doi: 10.1016/j.vetpar.2015.07.031.

Koziol U, Radio S, Smircich P, Zarowiecki M, Fernández C, Brehm K (2015). A Novel Terminal-Repeat Retrotransposon in Miniature (TRIM) Is Massively Expressed in Echinococcus multilocularis Stem Cells. Genome Biol Evol. 7(8):2136-53. doi: 10.1093/gbe/evv126.

Smircich P, Eastman G, Bispo S, Duhagon MA, Guerra-Slompo EP, Garat B, Goldenberg S, Munroe DJ, Dallagiovanna B, Holetz F, Sotelo-Silveira JR. (2015) Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi. BMC Genomics. 16:443. doi: 10.1186/s12864-015-1563-8.

Carvalhal S, Ribeiro SA, Arocena M, Kasciukovic T, Temme A, Koehler K, Huebner A, Griffis ER. (2015) The nucleoporin ALADIN regulates Aurora A localization to ensure robust mitotic spindle formation. Mol Biol Cell. 26(19):3424-38. doi: 10.1091/mbc.E15-02-0113


Prieto D., Aparicio G., Morande P.E., Zolessi F.R. (2014) A fast, low cost, and highly efficient fluorescent DNA labeling method using methyl green. Histochem Cell Biol 142(3):335-45. doi: 10.​1007/​s00418-014-1215-0

Tinoco L.W., Fraga J.L., AnoBom C.D., Zolessi F.R., Obal G., Toledo A., Pritsch O., Arruti C. (2014) Structural characterization of a neuroblast-specific phosphorylated region of MARCKS. Biochim Biophys Acta 1844(4): 837-849.

Brehm K, Koziol U (2014). On the importance of targeting parasite stem cells in anti-echinococcosis drug development. Parasite 21:72. doi: 10.1051/parasite/2014070.

Schubert A, Koziol U, Cailliau K, Vanderstraete M, Dissous C, Brehm K. (2014) Targeting Echinococcus multilocularis stem cells by inhibition of the Polo-like kinase EmPlk1. PLoS Negl Trop Dis. 8(6):e2870. doi: 10.1371/journal.pntd.0002870. 

Koziol U, Rauschendorfer T, Zanon Rodríguez L, Krohne G, Brehm K (2014). The unique stem cell system of the immortal larva of the human parasite Echinococcus multilocularis. Evodevo. 5(1):10. doi: 10.1186/2041-9139-5-10.

Skinner DE, Rinaldi G, Koziol U, Brehm K, Brindley PJ. (2014) How might flukes and tapeworms maintain genome integrity without a canonical piRNA pathway? Trends Parasitol. 30(3):123-9. doi: 10.1016/

Domínguez MF, Koziol U, Porro V, Costábile A, Estrade S, Tort J, Bollati-Fogolin M, Castillo E. (2014) A new approach for the characterization of proliferative cells in cestodes. Exp Parasitol. 2014 Mar;138:25-9. doi: 10.1016/j.exppara.2014.01.005. 

Hemer S, Konrad C, Spiliotis M, Koziol U, Schaack D, Förster S, Gelmedin V, Stadelmann B, Dandekar T, Hemphill A, Brehm K. (2014) Host insulin stimulates Echinococcus multilocularis insulin signalling pathways and larval development. BMC Biol. 2014 12:5. doi: 10.1186/1741-7007-12-5.

Contreras-Vallejos E, Utreras E, Bórquez DA, Prochazkova M, Terse A, Jaffe H, Toledo A, Arruti C, Pant HC, Kulkarni AB, González-Billault C. (2014) Searching for novel Cdk5 substrates in brain by comparative phosphoproteomics of wild type and Cdk5-/- mice. PLoS One. 9(3):e90363. doi: 10.1371/journal.pone.0090363.

Arezo MJ, Papa N, Gutiérrez G, García G, Berois N. (2014) Sex determination in annual fishes: searching for the master sex-determining gene in Austrolebias charrua (Cyprinodontiformes, Rivulidae). Genetics and Molecular Biology. 37. 364 – 374. doi: 10.1590/S1415-47572014000300008

Berois N, Arezo MJ, de Sà R. (2014) The Neotropical Genus Austrolebias: An Emerging Model of Annual Killifishes. Cell Dev Biol 3: 136. Doi: 10.4172/2168-9296.1000136

Shigunov P, Sotelo-Silveira J, Stimamiglio MA, Kuligovski C, Irigoín F, Badano JL, Munroe D, Correa A, Dallagiovanna B. (2014) Ribonomic analysis of human DZIP1 reveals its involvement in ribonucleoprotein complexes and stress granules. BMC Mol Biol. 15:12. doi: 10.1186/1471-2199-15-12


Koziol U, Krohne G, Brehm K. (2013) Anatomy and development of the larval nervous system in Echinococcus multilocularis. Front Zool. 10(1):24. doi: 10.1186/1742-9994-10-24.

Tsai IJ, Zarowiecki M, Holroyd N, Garciarrubio A, Sanchez-Flores A, Brooks KL, Tracey A, Bobes RJ, Fragoso G, Sciutto E, Aslett M, Beasley H, Bennett HM, Cai J, Camicia F, Clark R, Cucher M, De Silva N, Day TA, Deplazes P, Estrada K, Fernández C, Holland PW, Hou J, Hu S, Huckvale T, Hung SS, Kamenetzky L, Keane JA, Kiss F, Koziol U, Lambert O, Liu K, Luo X, Luo Y, Macchiaroli N, Nichol S, Paps J, Parkinson J, Pouchkina-Stantcheva N, Riddiford N, Rosenzvit M, Salinas G, Wasmuth JD, Zamanian M, Zheng Y; Taenia solium Genome Consortium, Cai X, Soberón X, Olson PD, Laclette JP, Brehm K, Berriman M. (2013) The genomes of four tapeworm species reveal adaptations to parasitism. Nature. 496(7443):57-63. doi: 10.1038/nature12031. 

Toledo A., Zolessi F.R., Arruti C. (2013) A novel effect of MARCKS phosphorylation by activated PKC: the dephosphorylation of its serine 25 in chick neuroblasts. PLOS ONE 8(4): e62863. DOI: 10.1371/journal.pone.0062863

Ruiz-Perera L.M., Arruti C., Zolessi F.R. (2013) Early phosphorylation of MARCKS at Ser25 in migrating precursor cells and differentiating peripheral neurons. Neurosci. Lett. 544: 5-9. DOI: 10.1016/j.neulet.2013.02.042

2012 y previos

Berois N, Arezo MJ, Papa N, Clivio G. (2012) Annual fish: facing harsh environment through developmental strategies. WIREs Developmental Biology (Wiley Interdisciplinary Reviews). doi: 10.1002/wdev.39.

Martin-Granados C, Prescott AR, Van Dessel N, Van Eynde A, Arocena M, Klaska IP, Görnemann J, Beullens M, Bollen M, Forrester JV, McCaig CD. (2012) A role for PP1/NIPP1 in steering migration of human cancer cells. PLoS One. 7(7):e40769. doi: 10.1371/journal.pone.0040769

Koziol U, Costábile A, Domínguez MF, Iriarte A, Alvite G, Kun A, Castillo E. (2011) Developmental expression of high molecular weight tropomyosin isoforms in Mesocestoides corti. Mol Biochem Parasitol. 175(2):181-91. doi:10.1016/j.molbiopara.2010.11.009. 

Randlett O., Poggi L., Zolessi F.R, Harris W.A. (2011) The oriented emergence of axons from retinal ganglion cells is directed by Laminin contact in vivo. Neuron 70(2): 266-280. doi: 10.1016/j.neuron.2011.03.013

Allende M.L., Calcaterra N.B., Vianna M.R., Zolessi F.R. (2011) First meeting of the Latin American Zebrafish Network (LAZEN). Zebrafish 8(1): 1-3. doi: 10.1089/zeb.2010.0687

Berois N, Arezo MJ, Papa N. (2011) Gamete interactions in teleost fishes: the egg envelope. Basic knowledge and perspectives as environmental biomonitor. Biological Research. 44. 119-124.

Koziol U, Domínguez MF, Marín M, Kun A, Castillo E. (2010) Stem cell proliferation during in vitro development of the model cestode Mesocestoides corti from larva to adult worm. Front Zool. 7:22. doi: 10.1186/1742-9994-7-22.

Amarelle V, Koziol U, Rosconi F, Noya F, O'Brian MR, Fabiano E (2010). A new small regulatory protein, HmuP, modulates haemin acquisition in Sinorhizobium meliloti. Microbiology. 156(Pt 6):1873-82. doi: 10.1099/mic.0.037713-0. 

Zolessi F.R., Sotelo-Silveira J. (2010) “La célula en cuatro dimensiones”. Cap. 4. en: Biología: unidad en la diversidad. Eds.: Tassino B., Silva A. Dirac, Facultad de Ciencias, Universidad de la República, Uruguay.

Koziol U, Hannibal L, Rodríguez MC, Fabiano E, Kahn ML, Noya F. (2009) Deletion of citrate synthase restores growth of Sinorhizobium meliloti 1021 aconitase mutants. J Bacteriol. 191(24):7581-6. doi: 10.1128/JB.00777-09.

Koziol U, Iriarte A, Castillo E, Soto J, Bello G, Cajarville A, Roche L, Marín M (2009). Characterization of a putative hsp70 pseudogene transcribed in protoscoleces and adult worms of Echinococcus granulosus. Gene. 443(1-2):1-11. doi: 10.1016/j.gene.2009.05.004.

Koziol U, Lalanne AI, Castillo E. (2009) Hox genes in the parasitic platyhelminthes Mesocestoides corti, Echinococcus multilocularis, and Schistosoma mansoni: evidence for a reduced Hox complement. Biochem Genet. 47(1-2):100-16. doi: 10.1007/s10528-008-9210-6.

Zolessi F.R. (2009) Vertebrate neurogenesis: cell polarity (v. 2). Encyclopedia of Life Sciences (Wiley). 

Lafon-Hughes L, Di Tomaso MV, Liddle P, Toledo A, Reyes-Ábalos AL, Folle GA. (2013) Preferential localization of γH2AX foci in euchromatin of retina rod cells after DNA damage induction. Chromosome Res. 21(8):789-803. doi: 10.1007/s10577-013-9395-3.

Toledo A, Arruti C. (2009) Actin modulation of a MARCKS phosphorylation site located outside the effector domain. Biochem Biophys Res Commun. 2009 Jun 5;383(3):353-7. doi: 10.1016/j.bbrc.2009.04.029.

García G, Loureiro M, Berois N, Arezo MJ, Casanova G, Clivio G, Olivera A. (2009) Pattern of differentiation in the annual killifish genus Austrolebias (Cyprinodontiformes; Rivulidae) from a Biosphere reserve site in South America: a multidisciplinary approach. Biological Journal of the Linnean Society. 98, doi: 620-635. 10.1111/j.1095-8312.2009.01303.x

Koziol U, Marín M, Castillo E. (2008) Pumilio genes from the Platyhelminthes. Dev Genes Evol. 218(1):47-53. doi: 10.1007/s00427-007-0200-1.

Arezo MJ, D´Alessandro S, Papa N, de Sà R, Berois N. (2007) Sex differentiation pattern in the annual fish Austrolebias charrúa (Cyprinodontiformes: Rivulidae). Tissue & Cell. 39, 89-98. Doi:

Gutiérrez V, Arezo MJ, García G. (2007) Characterization of partial Hox genes in annual fishes of the Cynolebiatinae subfamily (Cyprinodontiformes, Rivulidae). Genetics and Molecular Biology. 30, 494-503.

Berois N, Arezo MJ, Chalar C, Brauer M, Barros C. (2007) Ultrastructure and protein composition of the oocyte envelope in the whitemouth croacker, (Micropogonias furnieri, Desmarest, 1823, Sciaenidae, Perciformes). J. Appl. Ichthyol. 23.34-39. doi: 10.1111/j.1439-0426.2006.00762.x

Zolessi F.R., Poggi L., Wilkinson C.J., Chien C.-B., Harris W.A. (2006) Polarization and orientation of retinal ganglion cells in vivo. Neural Develop. 1: 2. DOI: 10.1186/1749-8104-1-2

Poggi L.*, Zolessi F.R.*, Harris W.A. (2005) Time-lapse analysis of retinal differentiation. Curr Opin Cell Biol. 17: 676-681. 

Arezo MJ, Pereiro L, Berois N. (2005) Early development in the annual fish Cynolebias viarius (Cyprinodontiformes: Rivulidae). Journal of Fish Biology. Vol.66, 1357-1370. doi: 10.1111/j.0022-1112.2005.00688.X

Zolessi F.R., Arruti C. (2004) MARCKS in advanced stages of neural retina histogenesis. Dev. Neurosci. 26: 371-379.

Zolessi F.R., Durán R., Engström U., Cerveñansky C., Hellman U., Arruti C. (2004) Identification of the chicken MARCKS phosphorylation site specific for differentiating neurons as Ser 25 using a monoclonal antibody and mass spectrometry. J. Proteome Res. 3: 84-90.

Zolessi F.R., Arruti C. (2001) Sustained phosphorylation of MARCKS in differentiating neurogenic regions during chick embryo development. Brain Res. Dev. Brain Res. 130: 257-267.

Zolessi F.R., Arruti C. (2001) Apical accumulation of MARCKS in neural plate cells during neurulation in the chick embryo. BMC Dev. Biol. 1: 7. DOI: 10.1186/1471-213X-1-7

Arruti C., Zolessi F.R. (2001) Cap. 1, “Neurogénesis en la retina: variantes fosforilados de MARCKS”. Cap. 14, “Generación de anticuerpos monoclonales contra tejidos embrionarios: método de fusión clonado”. Cap. 15, “Separación de polipéptidos por SDS-D-1D (Método de Arruti y Chifflet)”. En Neurogénesis: Aspectos celulares y moleculares del desarrollo neural embrionario. Eds.: Carri, Goya y Rovasio, IMBICE y Ac. Nal. Cs. Exactas, Físicas y Naturales, Buenos Aires, Argentina.

Zolessi F.R., Hellman U., Baz A., Arruti C. (1999) Characterization of MARCKS (Myristoylated Alanine-Rich C Kinase Substrate) identified by a monoclonal antibody generated against chick embryo neural retina. Biochem. Biophys. Res. Commun. 257: 480-487.